End-Plate Acetylcholine Receptor: Structure, Mechanism, Pharmacology, and Disease
نویسندگان
چکیده
منابع مشابه
End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease.
The synapse is a localized neurohumoral contact between a neuron and an effector cell and may be considered the quantum of fast intercellular communication. Analogously, the postsynaptic neurotransmitter receptor may be considered the quantum of fast chemical to electrical transduction. Our understanding of postsynaptic receptors began to develop about a hundred years ago with the demonstration...
متن کاملOn the mechanism of calcium actions on the acetylcholine receptor-channel complex at the frog end-plate membrane.
The mechanism of depressant effects of Ca2+ on the acetylcholine (ACh)-activated ion channel conductance was studied in frog muscle fibers. Increasing the extracellular Ca2+ ( (Ca2+)o) suppressed the increase in the end-plate conductance induced by iontophoretic application of ACh and shifted the reversal potential for a neurally-induced end-plate current to a more negative value. The single ch...
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and 'Immunological associations of acquired neuromyotonia (Isaacs' syndrome). Report of five cases and literature review'. John Newsom-Davis published 12 original articles in Brain. Many dealt with autoimmunity in disorders of the neuromuscular junction or peripheral nerve. Together this work provided a foundation for knowledge on disorders resulting from autoantibodies directed at the acetylch...
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Nicotinic acetylcholine receptors are allosteric proteins that generate membrane currents by isomerizing ("gating") between resting and active conformations under the influence of neurotransmitters. Here, to explore the mechanisms that link the transmitter-binding sites (TBSs) with the distant gate, we use mutant cycle analyses to measure coupling between residue pairs, phi value analyses to se...
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Abstract: Aims: End of Life (EOL) care providers potentially face by variety of legal and professional dilemma. This study is designed to review and analyze these challenges and approaches to solve them. Materials & Methods: In this narrative review study, legal aspects of end-of-life care in subjects such as medical assisted dying, decision-making capacity and withdrawal of life-sustaining...
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ژورنال
عنوان ژورنال: Physiological Reviews
سال: 2012
ISSN: 0031-9333,1522-1210
DOI: 10.1152/physrev.00015.2011